Founded in early 2005, StratiCELL is a leading company assisting the cosmetic, pharmaceutical and chemical industries to the safety and efficacy evaluation of their actives and products by means of in vitro models and methods in a GLP-compliant environment.

StratiCELL is a skin model manufacturer and a project-driven services provider for in vitro testing, with a particular emphasis on testing of skin care actives and products

Reconstituted Human Epidermis : RHE – EPI/001

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Cells are seeded on polycarbonate filters grown at the air-liquid interface with appropriate cell culture medium, free of animal serum. After two weeks of differentiation, a full epidermis is reconstituted. The StratiCELL® reconstituted epidermis is very similar to human skin in terms of morphology, of differentiation markers and of functional characteristics.


Indeed, StratiCELL® reconstituted human epidermis model consists of a living, epidermal tissue fully stratified and differentiated as demonstrated by the expression profile of keratin 14, keratin 10 and involucrin. StratiCELL® tissues also synthesize inflammatory cytokines (IL-1α and IL8) following the exposure to irritant or sensibilizing agents, respectively.


This model represents a relevant tool for safety and dermato-cosmetic activity testing, for penetration and absorption studies and for providing insights into mechanisms of action of an active or product.

 

RHE-EPI/001 is commercially available. Please contact us at This e-mail address is being protected from spambots. You need JavaScript enabled to view it for prices and delivery dates.