Anti-ageing and detoxification

 

Available assays dedicated to address skin ageing-related processes include among others :

  • Collagen deposition (mRNA, protein)
  • MMPs production (mRNA, protein, proteolytic activity)
  • Extracellular matrix components (mRNA, protein)
  • Reactive oxygen species (H2DCFDA)
  • Protection agains stress-induced premature senescence (SIPS)
  • Senescence-associated β-galactosidase activity
  • Proteasome activity
  • Stress response (p53, HSPs, NRF-2 pathway)
  • Proliferation and apoptosis
  • DNA damage
  • Age spots
  • Fibroblasts contractility using collagen lattices
  • Detoxification pathway