Sun protection

 

Multi-parametric endpoints targeting early and late biological processes appearing after acute sun exposure are measured.

The biological activity of a substance in photo-protection and repair can be evaluated through specific histological staining of sections of ex vivo skin or reconstituted in vitro epidermis, using different biomarkers for DNA damage (cyclobutane pyrimidine dimers), stress response (p53, HSPs, NRF-2 pathway), apoptosis (caspase-3, sunburn cells) and inflammation (Langerhans cells phenotype, cytokine production).