Ex vivo skin

 

Ex vivo human skin from abdominal surgery is used to study hydrophobic or formulated compounds, and is the gold standard for percutaneous absorption studies using Franz diffusion cells.

Ex vivo skin is particularly suitable to address sun protection with dedicated biomarkers like pyrimidine dimers, p53 activation, caspase activation and sunburn cells, based on histology and immuno-labeling. It is also widely used for transcriptomic studies from samples coming from studies on human volunteers.