Founded in early 2005, StratiCELL is a leading company assisting the cosmetic, pharmaceutical and chemical industries to the safety and efficacy evaluation of their actives and products by means of in vitro models and methods in a GLP-compliant environment.
StratiCELL is a skin model manufacturer and a project-driven services provider for in vitro testing, with a particular emphasis on testing of skin care actives and products
StratiCELL performs in vitro skin absorption testing according OECD 428 testing guideline.
Dermal penetration testing, also known as percutaneous absorption, measures the absorption or penetration through the skin barrier and into the skin.
The screen determines relative flux rates, transdermal permeability, cytotoxicity, and metabolic stability of different compounds or different formulations of the same compound after topical application. Penetration of actives from particles could be quantified or visualized using fluorescent probes.
The test substance is applied to the surface of a skin sample separating two chambers of a diffusion cell. The chemical remains on the skin for a specified time under specified conditions, before removal by an appropriate cleansing procedure. The receptor fluid is sampled at time points throughout the experiment and analysed for the test chemical and/or metabolites.