Partenaire privilégié de l'industrie cosmétique, pharmaceutique et chimique, StratiCELL, société fondée début 2005, caractérise l'inocuité et l'efficacité dermo-cosmétique de différents actifs et produits au moyen de modèles et de tests in vitro et ce, dans un environnement BPL.
L'activité de StratiCELL est axée sur la production et la commercialisation d'épidermes reconstitués, destinés aux tests in vitro. Par ailleurs, StratiCELL preste de nombreux services qui permettent de caractériser les produits à usage cutané.
Sun Protection
Ultraviolet radiations can lead to photodamage causing long-term consequences as photoaging and photocarcinogenesis. In response to UV a battery of biological activities in the skin are switched-on in order to protect the body. In vitro, UV-exposure of skin biopsies or reconstituted epidermis leads to similar biological responses. StratiCELL proposes endpoints to evaluate a photo-protective or a photo-repairing effect of a skin care substance. . |
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In vitro biological endpoints for Sun Protection
- Quantification of DNA damage (Cyclobutane Pyrimidine Dimers, CPDs)
- Response to stress (activity of p53, heat shock proteins, stress-associated protein kinases)
- Apoptosis (measuring the caspase-3 activity, TUNEL, and the formation of sunburn cells)
- Skin Inflammation
- Gene expression profiling
Skin biology processes after sun exposure
Labeling of Sun Burn Cells, DNA damage (Cyclobutane Pyrimidine Dimers), p53 stress protein, caspase-3 in human skin biopsies that have been either un-exposed or UV-exposed in absence and in presence of a sunscreen. |
UV-exposure induces DNA damage, such as CPD's. The protein p53 is also activated. When too many DNA damages occur, the cell enters the apoptotic cascade process -among others caspase-3 gets activated-, which leads to cell death, and prevents transformation into a carcinogenic cell.
In Vitro Sun Protection technical sheet
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