Partenaire privilégié de l'industrie cosmétique, pharmaceutique et chimique, StratiCELL, société fondée début 2005, caractérise l'inocuité et l'efficacité dermo-cosmétique de différents actifs et produits au moyen de modèles et de tests in vitro et ce, dans un environnement BPL.
L'activité de StratiCELL est axée sur la production et la commercialisation d'épidermes reconstitués, destinés aux tests in vitro. Par ailleurs, StratiCELL preste de nombreux services qui permettent de caractériser les produits à usage cutané.
StratiCELL MEL/001
Applications of the StratiCELL® Reconstituted Epidermis with Melanocytes
- In vitro de- and pro-pigmentation studies of skin care substances and products (systemic way);
- Screening of molecular pathways involved in melanogenesis;
- Gene expression profiling with proprietary TaqMan® arrays.
The StratiCELL® Reconstituted Epidermis with Melanocytes (MEL/001) is produced from human keratinocytes isolated from neonatal skin tissue from a pool of different donors, and from melanocytes from Black (MEL/001 DT) or Caucasian (MEL/001 LT) donors.
Cells are seeded on polycarbonate filters (standard size 0.63 cm2) and grown at the air-liquid interface in an appropriate cell culture medium. After two weeks of differentiation, a full pigmented epidermis is reconstituted.
For each batch of reconstituted pigmented human epidermis, the quality of the tissues is verified and detailed in a quality data sheet.
StratiCELL has developed its proprietary reconstituted pigmented epidermis. The StratiCELL® Reconstituted Epidermis with Melanocytes (MEL/001) is commercially available. Their quality and high reproducibility make them ideal for use in alternatives to animal testing.
The StratiCELL® Reconstituted Epidermis with Melanocytes (MEL/001), melanin is visualized with a Fontana Masson staining on tissue sections
