Founded in early 2005, StratiCELL is a leading company assisting the cosmetic, pharmaceutical and chemical industries to the safety and efficacy evaluation of their actives and products by means of in vitro models and methods in a GLP-compliant environment.
StratiCELL is a skin model manufacturer and a project-driven services provider for in vitro testing, with a particular emphasis on testing of skin care actives and products
In Vitro Penetration Studies
Driven by legislative requirements, skin penetration and absorption studies are becoming essential for safety and efficacy evaluation of test substances or formulations.
In vivo, substances topically applied onto the skin surface can diffuse into and penetrate through the skin using three distinct pathways, namely the intercellular and the transcellular route across the stratum corneum as well as the route along the skin appendages (hair follicles & sweat glands).
Both the percutaneous penetration and the absorption into different skin compartments of your test substances can be evaluated by StratiCELL using in vitro alternative assays.
In vitro skin penetration (Technical sheet on Penetration & Skib Absorption)
In vitro skin penetration studies can be performed using different types of in vitro skin models (human or animal, full-thickness or dermatomed skin biopsies as well as reconstituted human epidermis). These studies are used for:
- Evaluation of penetration kinetics of actives;
- Evaluation of bioavailability of actives in different types of formulations;
- Comparison with other actives and/or formulations.
OECD guideline 428
PDF document on OECD GUIDELINE FOR THE TESTING OF CHEMICALS (Skin absorption - in vitro Method) - OECD Website
The OECD Test Guideline 428 "Skin Absorption: In Vitro Method" provides information on the absorption profile of a substance applied to skin biopsies. This assay, often combined with penetration studies, is fundamental for obtaining information related to the delivery of the active into the different skin layers.
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| Franz cells, a powerful tool for skin penetration/absorption studies |
