Bibliography : StratiCELL & Laboratory of Cell Biology, University of Namur, Belgium

Articles in peer-reviewed journals (from 2000 onwards).

Scheckhuber, Grief, Boilan, Luce, Chainiaux -Debacq, Rittmeyer, Gredilla, Kolbesen, Toussaint & Osiewacz. Age-Related Cellular Copper Dynamics in the Fungal Ageing Model Podospora anserina and in Ageing Human Fibroblasts, Plos one, 4, 3, 1-14, 2009

Piret, Detriche, Vigneron, Vankoningsloo, Rolin, Mejia Mendoza, Masereel, Lucas, Delhalle, Luizi, Saout & Toussaint. Dispersion of multi-walled carbon nanotubes in biocompatible dispersants, Journ of Nanop Res, 2009

Zdanov, Toussaint, Chainiaux -Debacq. p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblast, Biogerontol, 10, 291-298, 2009

Chrétien, Piront, Delaive, Demazy, Ninane & Toussaint. Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblast in H2O2-induced premature senescence and interplay with p38alphaMAPK, FEBS lett, 582, 12, 1685-1692, 2008

Glotin, Chainiaux -Debacq, Brossas, Faussat, Treton, Zubielewicz, Toussaint & Mascarelli. Prematurely senescent ARPE-19 cells display features of age-related macular degeneration, Free Rad Biol& Med, 44, 1348-1361, 2008

Borlon, Vankoningsloo, Godard, Chainiaux -Debacq & Toussaint. Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblast using siRNA technology, Mech of Ageing and Dev, 129, 3, 109-119, 2008

Chainiaux -Debacq, Pascal, Boilan, Bastin, Bauwens& Toussaint. Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblast, Free Rad Biol & Med, 44, 1817-1832, 2008

Chrétien, Dierick, Delaive, Rossel-Larsen, Dieu, Raes, Deroanne, Roepstorff & Toussaint. Role of TGF-beta1-independent changes in protein neosynthesis, p38alpha MAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis, Free Rad Biol & Med, 44, 9, 1732-1751, 2008

Chrétien, Delaive, Dieu, Demazy, Ninane, Raes & Toussaint. Upregulation of annexin A2 in H202-induced premature senescence as evidence by 2D-DIGE proteome analysis, Exp Gerontol, 43, 353-359, 2008

Bigot, Jacquemin, Chainiaux -Debacq, Butler-Browne, Toussaint, Furling, Mouly. Replicative aging down-regulates the myogenic regulatory factors in human myoblasts, Biol. Cell, 100, 3, 189-199, 2008

Mortensen, Sorensen, Wilde, Dragoni, Mullerova, Toussaint, Zloch, Sgaragli, Ovesna. Biological models for phytochemical research: from cell to human organism, British Journ of Nutr, 99, E-Suppl 1, 118-126, 2008

Borlon, Weemaels, Godard, Chainiaux -Debacq, Lemaire, Deroanne & Toussaint. Expression profiling of senescent-associated genes in human dermis from young and old donors. proof-of-concept study, Biogerontol, 9, 3, 197-208, 2008

Ovesna, Sslaby, Toussaint, Kodicek, Marsik, Pouchova & Vanek. High throughput 'omics' approaches to assess the effects of phytochemicals in human health studies, British Jour of Nutr, 99, 130-137, 2008

Pascal, Chainiaux -Debacq, Boilan, Ninane, Raes & Toussaint. Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblast induced by tert-butylhydroperoxide and ethanol, Biogerontol, 8, 409-422, 2007

Chainiaux -Debacq, Borlon, De hertogh, Remacle, Morvan, Vallee & Toussaint. Identification of potential anti-photoageing algal compounds using an in-vitro model of photoageing, Journ of Pharm and Pharmacol, 58, 1577-1583, 2006

Zdanov, Chainiaux -Debacq, Remacle & Toussaint. Identification of p38(MAPK)-dependent genes with changed transcript abundance in H(2)O(2)-induced premature senescence of IMR-90 hTERT human fibroblasts. FEBS Lett, 580, 27, 6455-6463, 2006

Pascal, Debacq-Chainiaux, Chrétien, Bastin, Dabée, Bertholet, Remacle & Toussaint. Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett, 579, 3651-3659, 2005.

Debacq-Chainiaux, Borlon, Pascal, Royer, Carrard, de Longueville, Boffe, Eliaers, Friguet, Remacle & Toussaint. Repeated exposures of human skin fibroblasts to UVB at subcytotoxic level trigger premature senescence through the TGF-ß1 signaling pathway. J Cell Sci, 118, 743-758, 2005.

de Magalhães, Costa & Toussaint. HAGR : The Human Ageing Genomic Resources. Nucl Acid Res, 33, D537-543, 2005

Human Ageing Research Resource, by M. Skipper Nature Reviews Genetics, 5, 330, 2004. On computational databank by O. Toussaint and JP Magalhaes.

(Data)base Desires. New resource compiles genes that potentially influence human aging http://sageke.sciencemag.org/cgi/content/full/2004/30/nf69 by R. John Davenport. On computational databank by O. Toussaint and JP Magalhaes.

Matthews, Haimes, Duguet, Clark, Swine & Toussaint. Informed consent of very old patients and modern genomics. Biogerontology, 6, 81-84, 2005

de Magalhães & Toussaint. GenAge: a genomic and proteomic network map of human ageing. FEBS Lett, 571, 243-247, 2004.

de Magalhaes, Chainiaux, de Longueville, Mainfroid, Migeot, Marcq, Remacle, Salmon & Toussaint. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Exp Gerontol,39, 1379-1389, 2004

Salmon, Dedessus Le Moutier, Wenders, Chiarizia, Eliaers, Remacle, Royer, Pascal & Toussaint. Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress. FEBS Lett, 557, 25-32, 2004

Toussaint, Remacle, Dumont, Dierick, Pascal, Frippiat, Magalhaes & Chainiaux. Oxidative stress-induced senescence of human diploid cells. Nature Encyclopedia of Life Science (Macmillan, Nature Publishing group). http://www.els.net article 3441, version 2., 2004

de Magalhaes & Toussaint. Telomeres and telomerase, a modern Fountain of Youth? Rejuvenation Research, 7, 126-133, 2004

Toussaint. View of a young biogerontologist on the in vitro biogerontological model systems. Editorial. Exp. Gerontol., 38, 1229-1230, 2003

Toussaint, Salmon, Royer, Dierick, de Magalhaes, Wenders, Zdanov, Chrétien, Borlon, Pascal & Chainiaux. Role of subcytotoxic stress in tissue ageing. Biomarkers of senescence, signal transduction and proteomics in stress-induced premature senescence. In : Topics in Current Genetics. T. Nyström & H.D. Osiewacz (eds) Springer Verlag (Berlin), vol 3, 269-294, 2003.

Toussaint. Normal brain aging: a commentary. Neurobiol. Aging, 24, Suppl. 1, S129-S130, 2003

Dierick, Frippiat, Salmon, Chainiaux & Toussaint. Cells, stress and tissue ageing. In : Biology of Aging and its Modulation. S.I.S. Rattan (Series ed) Vol. 5 : Modulating aging and longevity, S.I.S. Rattan (ed), Kluwer (Amsterdam), 101-125, 2003

Carrard, Dieu, Raes, Toussaint & Friguet. Impact of aging on proteasome structure and function in human lymphocytes. Int. J. Biochem. Cell Biol. 35, 728-739, 2002

Frippiat , Remacle & Toussaint. Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int. J. Biochem. Cell Biol., 35, 246-254, 2003

Frippiat, Dewelle, Remacle & Toussaint. Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblasts. Free Rad. Biol. Med., 33, 1334-1346, 2002

Dierick, Kalume, Wenders, Salmon, Dieu, Raes, Roepstorff & Toussaint. Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence. FEBS Lett, 531, 499-504, 2002.

Magalhaes, Chainiaux, Remacle & Toussaint. Stress-induced premature senescence in BJ and hTERT-BJI human diploid fibroblasts. FEBS Lett. 523 157-162, 2002

Dierick, Eliaers, Remacle, Raes, Fey, Mose Larsen & Toussaint. Stress-induced premature senescence and replicative senescence are different phenotypes. Proteomic evidence. Biochem. Pharmacol. 64, 1011-1017, 2002

Toussaint, Royer, Salmon, Remacle. Stress-induced premature senescence and tissue ageing. Biochem. Pharmacol. 64, 1007-1009, 2002.

Toussaint, Dumont, Dierick, Pascal, Frippiat, Zdanov, Magalhaes, Royer & Chainiaux. Hayflick mosaic or stress-induced premature senescence ? Is it stress-induced premature senescence or replicative senescence that occurs in vivo ? Int. J. Biochem. Cell Biol. 34, 1415-1429, 2002

Chainiaux, Magalhaes, Eliaers, Remacle & Toussaint. UV-B induced premature senescence of human diploid skin fibroblasts. Int. J. Biochem. Cell Biol. 34, 1331-1339, 2002

Dierick, Dieu, Remacle, Raes, Roepstorff & Toussaint. Proteomics in experimental gerontology. Exp. Gerontol. 37, 721-734, 2002

Magalhães & Toussaint. The Evolution of Mammalian Aging. Exp. Gerontol. 37, 769-775, 2002.

Dumont, Chainiaux, Eliaers, Petropoulou, Remacle, Koch-Brandt, Gonos & Toussaint. Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxyde. Cell Stress & Chaperones 7 , 23-35, 2002.

Toussaint, Remacle, Dumont, Dierick, Pascal, Frippiat, Royer & Chainiaux. Stress-induced premature senescence : from biomarkers to likeliness of in vivo occurence. Biogerontology. 3, 13-17, 2002

Toussaint, Remacle, Dierick, Pascal, Frippiat, Royer & Chainiaux. Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics. Mech. Ageing Dev. 123, 937-946, 2002

Toussaint, Salmon, Dierick, de Magalhaes, Pascal, Zdanov, Wenders, Borlon, Chrétien, Chiarizia, Remacle, de Longueville, Zammatteo & Chainiaux. TOXICO-SIPS. Development of a valuable tool of in vitro toxicology, toxicoproteomics and toxicotranscriptomics based on stress-induced premature senescence (SIPS). Applied Genomics Proteomics 1, 227-324, 2002.

Chainiaux, Remacle & Toussaint. Exposure of skin human diploid fibroblasts to repeated subcytotoxic doses of UVB induces the overexpression of the TGF-b1 mRNA. Ann. NY Acad. Sci. 973, 44-48, 2002

Toussaint, Dumont, Remacle, Dierick, Pascal, Frippiat, Magalhaes, Zdanov & Chainiaux. Stress-induced premature senescence or stress-induced senescence-like phenotype : one in vivo reality, two possible definitions ? How stress, cellular behaviors, growth kinetics and cell heterogeneity interact in senescence. Scientific World J.. 2, January, 230-247, 2002 http://www.thescientificworld.com

Frippiat, Chen, Zdanov, Magalhaes, Remacle & Toussaint. Subcytotoxic H2O2 stress triggers a release of Transforming Growth Factor-ß1, which induces stress-induced premature senescence of human diploid fibroblasts. J. Biol. Chem. 276, 2531-2537, 2001.

Dumont, Royer, Pascal, Dierick, Chainiaux, Frippiat, Eliaers, Remacle & Toussaint. Growth kinetics rather than stress cause accelerated telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS Lett. 502, 109-112, 2001.

Petropoulou, Trougakos, Kolettas, Toussaint & Gonos. Clusterin/apolipoprotein J is a novel biomarker of senescence that does not affect the proliferative capacity of human diploid fibroblasts. FEBS Lett. 509, 287-297, 2001.

Toussaint, Remacle, Dierick, Pascal, Frippiat, Magalhaes & Chainaux. Hormesis : a quest for virtuality ? Human Exp. Toxicol., 20, 311-314, 2001.

Dumont & Toussaint. Raccourcissement des télomères et sénescence cellulaire. Rev. Gériatr. 26, 719-728, 2001.

Dumont & Toussain. Pourquoi et comment vieillissons-nous ? Les théories du vieillissement. Rev. Gériatr. 26, 667-672, 2001

Brack, Lithgow, Osiewacz & Toussaint. Molecular and Cellular Gerontology. EMBO J. 19 1929-1934, 2000.

Toussaint, Remacle, Clark, Gonos, Franceschi & Kirkwood. Molecular, Cellular and Tissue Gerontology. BioEssays 22:954-956, 2000.

Chen, Tu, Catania, Burton, Toussaint & Dilley. Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide. J. Cell Sci., 113 (Pt 22), 4087-4097, 2000.

Dumont, Chen, Burton, Gonos, Frippiat, Mazarati, Eliaers, Remacle & Toussaint. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Rad. Biol. Med., 28, 361-373, 2000.

Frippiat, Chen, Remacle & Toussaint. Cell cycle regulation in H2O2-induced premature senescence of human diploid fibroblasts. Regulatory control exerted by the human papilloma virus E6 and E7 proteins. Exp. Gerontol., 35 (6-7) 733-746, 2000.

Toussaint, Medrano & Zglinicki. Stress-induced premature senescence of human diploid fibroblasts and melanocytes. Exp. Gerontol., 35 (8) 927-945, 2000.

Toussaint, Baret, Brion, Cras, Collette, De Deyn, Geenen, Kienlen-Campard, Labeur, Legros, Nève, Octave, Piérard, Salmon, van den Bosch de Aguilar, Van der Linden, Van Leuven & Vanfleteren. Experimental gerontology in Belgium: from model systems to age-related diseases. Invited review. Exp. Gerontol., 35 (8) 901-916, 2000.

Toussaint. Editorial. Biological ageing : Euroconference on Molecular, Cellular and Tissue Gerontology. Exp. Gerontol., 35 (6-7) 669-670, 2000.

Toussaint, Dumont, Dierick, Pascal, Frippiat, Chainiaux, Sluse, Eliaers & Remacle. Stress-Induced Premature Senescence. Essence of life, evolution, stress & aging. Ann. NY Acad. Sci., 908, 85-98, 2000.

Dumont, Burton, Chen, Frippiat, Pascal, Dierick, Remacle & Toussaint. Human diploid fibroblasts display a decreased level of c-fos mRNA at 72 hrs after exposure to sublethal H2O2 stress. Ann. NY Acad. Sci., 908 306-311, 2000.

Frippiat, Dierick, Remacle & Toussaint. Consideration of heteroduplexes and homoduplexes for the quantification by competitive PCR of deletions of human mitochondrial DNA with ageing of tissues and cells. Biogerontology, 1 (3), 279-283, 2000.

50. Toussaint, Dumont, Dierick, Pascal, Frippiat, Chainiaux, Magalhaes, Eliaers & Remacle. Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry. Biogerontology, 1 (2), 177-181, 2000.

Some of the book chapters published from 2000 onwards.

Toussaint, Chainiaux, Chrétien, Flament, Delaive & Dierick. Proteomics in ageing. In : Encyclopedic reference of genomics and proteomics in molecular medicine. Springer-Verlag, Heidelberg. Invited paper. In press

Dierick, Frippiat, Salmon, Chainiaux & Toussaint. Cells, stress and tissue ageing. In : Biology of Aging and its Modulation. S.I.S. Rattan (Series ed) Vol. 5 : Modulating aging and longevity, H.D. Osiewacz (ed), Kluwer (Amsterdam), 101-125, 2003

Toussaint, Salmon, Royer, Dierick, de Magalhaes, Wenders, Zdanov, Chrétien, Borlon, Pascal & Chainiaux. Role of subcytotoxic stress in tissue ageing. Biomarkers of senescence, signal transduction and proteomics in stress-induced premature senescence. In : Topics in Current Genetics. T. Nyström & H.D. Osiewacz (eds) Springer Verlag (Berlin), vol 3, 269-294, 2003.

Dumont, Chainiaux, Dierick, Remacle & Toussaint. Vieillissement cellulaire et sénescence réplicative In :Gérontologie Préventive. Eléments de prévention du vieillissement pathologique C. Trivalle (Ed.) Masson Editions, Paris. 25-34, 2002

Dumont, Royer, Frippiat, Pascal, Remacle & Toussaint. Radicaux libres et antioxydants dans le vieillissement In :Gérontologie Préventive. Eléments de prévention du vieillissement pathologique C. Trivalle (Ed.) Masson Editions, Paris. 35-49 2002