Founded in early 2005, StratiCELL is a leading company assisting the cosmetic, pharmaceutical and chemical industries to the safety and efficacy evaluation of their actives and products by means of in vitro models and methods in a GLP-compliant environment.
StratiCELL is a skin model manufacturer and a project-driven services provider for in vitro testing, with a particular emphasis on testing of skin care actives and products
Customized Epidermis
StratiCELL has developed a method to isolate, amplify and reconstruct epidermis from skin biopsies, or suction blistering (picture 1). This method allows to develop customized epidermis from patients suffering from skin diseases (psoriasis, dermatitis) or to compare epidermis of young donor (neonatal or 18 years - picture 2) to old donor (51 years - picture 3).
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picture 1 |
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Applications of the customized StratiCELL® Reconstituted Epidermis
- Identify molecular pathways involved in skin diseases
- Drug screening for skin pathologies
- Gene expression profiling with proprietary TaqMan® arrays
Cells are seeded on polycarbonate filters (standard size 0.63 cm2) and grown at the air-liquid interface in an appropriate cell culture medium.
After two weeks of differentiation, a full epidermis is reconstituted.
